Short sequence motif dynamics in the SARS-CoV-2 genome suggest a role for cytosine deamination in CpG reduction.
M. Sadykov, T. Mourier, Q. Guan, A. Pain
The paper analyzes SARS-CoV-2 genomic data to show increasing C-to-U substitutions over time, suggesting APOBEC-mediated RNA editing reduces CpG frequency to evade ZAP-mediated degradation.
bioRxiv · Jun 19, 2020Microbiology