Author

M. Sanderford

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Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Kumar· 1 shared B. M. Butler· 1 shared N. J. Ose· 1 shared S. B. Ozkan· 1 shared S. Kumar· 1 shared

Activity by Year

2021-2021 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperBiophysics

A. Kumar

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1 paper

Recent·Most cited

Dynamic coupling of residues within proteins as a mechanistic foundation of many enigmatic pathogenic missense variants

N. J. Ose, B. M. Butler, A. Kumar, M. Sanderford, S. Kumar, S. B. Ozkan

The paper identifies a mechanism by which pathogenic missense variants disrupt dynamic coupling between protein residues and functional sites, explaining dysfunction in enzymes with distant mutations.

bioRxiv · Sep 24, 2021Biophysics