N. J. Ose

Some mechanistic underpinnings of molecular adaptations of SARS-COV-2 spike protein by integrating candidate adaptive polymorphisms with protein dynamics

The paper integrates evolutionary predictions with protein dynamics to analyze molecular adaptations of SARS-CoV-2 Spike protein, revealing allosteric interactions and mutation effects on ACE2 binding and antibody escape.

Dynamic coupling of residues within proteins as a mechanistic foundation of many enigmatic pathogenic missense variants

The paper identifies a mechanism by which pathogenic missense variants disrupt dynamic coupling between protein residues and functional sites, explaining dysfunction in enzymes with distant mutations.