Cytokine signaling converging on IL11 in ILD fibroblasts provokes aberrant epithelial differentiation signatures
M. T. Kastlmeier, E. Gonzalez Rodriguez, P. Cabanis, E. M. Guenther, A.-C. Koenig, L. Han, S. Hauck, F. See, S. Asgharpour, C. Bukas, G. Burgstaller, M. Piraud, M. Lehmann, R. A. Hatz, J. Behr, , C. Voss
This study identifies IL11 as a key mediator of aberrant epithelial differentiation in ILD fibroblast-epithelial crosstalk using a 3D organoid co-culture model and secretome analysis.
bioRxiv · Dec 20, 2022Cell Biology