Sparse epistatic patterns in the evolution of terpene synthases
A. Ballal, C. Laurendon, M. Salmon, M. Vardakou, J. Cheema, P. E. O'Maille, A. V. Morozov
The paper investigates sequence determinants of enzyme activity and specificity in terpene synthases using biochemical and computational methods to model free energy landscapes and epistasis.
bioRxiv · Nov 10, 2019Evolutionary Biology