Somatic mutations in chronic lung disease are associated with reduced lung function
Jeong Hyun Yun, M.A. Wasay Khan, Auyon Ghosh, Brian D. Hobbs, Peter J. Castaldi, Craig P. Hersh, Peter Grant Miller, Carlyne D. Cool, Frank C. Sciurba, Lucas Barwick, ANDREW HAR LIMPER, Kevin R. Flaherty, Gerard J. Criner, Kevin K. Brown, Robert A. Wise, , Alexander G. Bick
The paper finds that somatic mutations in diseased lung tissue correlate with reduced lung function and cell type proportions in COPD and IPF.
medRxiv · Mar 3, 2023 · PreprintGenetic & Genomic Medicine