Frank C. Sciurba

This study identifies QKI as a regulator of mitochondrial integrity in COPD, showing its protective role against emphysema through maintenance of mitochondrial function.

The paper identifies miRNAs and isomiRs associated with COPD and ILD through integrative network analysis of RNA-seq and SNP data from lung tissue samples.

The paper finds that somatic mutations in diseased lung tissue correlate with reduced lung function and cell type proportions in COPD and IPF.

This study identifies 59 sentinel variants and two novel genes associated with telomere length using whole genome sequences from 109,122 trans-ethnic individuals.

The paper introduces SAT, a method that uses both paired and unpaired data to improve association tests between biomedical data types, showing better control of false discovery and increased power in real-world applications.