Multiparameter cell characterization using nanofluidic technology facilitates real-time phenotypic and genotypic elucidation of intratumor heterogeneity
Kristin G. Beaumont, Wissam Hamou, Nenad Bozinovic, Thomas R. Silvers, Hardik Shah, Arpit Dave, Kimaada Allette, Maya Strahl, Ying‐Chih Wang, Hanane Arib, Alesia Antoine, Ethan Ellis, Melissa Laird Smith, Brandon R. Bruhn, Peter Remsen Dottino, , Robert Sebra
The paper uses a nanofluidic platform to enable single-cell phenotypic and genetic profiling of ovarian cancer cells, revealing clonal diversity and TP53 mutation patterns associated with tumor heterogeneity.
bioRxiv · Oct 31, 2018 · PreprintGenomics