Kristin G. Beaumont

Plasticity of Human Microglia and Brain Perivascular Macrophages in Aging and Alzheimer's Disease

The paper profiles human myeloid cells across aging and Alzheimer's disease, identifies AD-associated changes, and links GPNMB to neuroprotection via TREM2.

A transcriptional continuum links viral burden and host-cell biology in human lymphoid tissue

This study shows HIV transcription spans a continuum in human lymphoid tissue, linking viral burden to host-cell biology and suggesting persistent viral activity reflects a spectrum of host-virus states.

Spatial multi-omics defines a shared infiltrative signature in glioblastoma at the resection margin

This study identifies a shared infiltrative signature in glioblastoma at the resection margin using spatial multi-omics data and validates EGFR as a key marker.

Mapping of Multilineage Tumor Cell Populations in Mouse Bladder Cancer

This study uses deep learning and reference atlases to analyze tumor cell populations in mouse bladder cancer, identifying lineage-specific subpopulations and their therapeutic vulnerabilities.

Multiscale mapping of transcriptomic signatures for cardiotoxic drugs

The paper identifies cardiotoxic drug signatures using bulk transcriptomics and integrates them with genomic and single-cell data to predict toxicity mechanisms.

Single cell view of tumor microenvironment gradients in pleural mesothelioma

This paper uses single-cell RNA-sequencing to analyze the tumor microenvironment in pleural mesothelioma, identifying gene programs, fetal-like endothelial cells, and a new therapeutic target.

Sexually dimorphic role of diet and stress on behavior, energy metabolism, and the ventromedial hypothalamus

This study investigates how diet and stress interact with sex to affect behavior, metabolism, and the ventromedial hypothalamus in mice, revealing sex-specific effects on fear memory, glucose levels, and metabolic parameters.

Spinal Cord Injury regulates circular RNA expression in axons

The paper identifies SCI-induced changes in axonal RNA, including circular RNAs, and shows that reducing ADAR1 promotes axonal outgrowth.

Single-cell Transcriptomic Atlas of the Human Substantia Nigra in Parkinson's Disease

This study generates a large single-cell RNA sequencing dataset of the human substantia nigra in Parkinson's disease, identifies DA neuron subtypes, and reveals molecular changes associated with PD.

Extracellular histones, a new class of inhibitory molecules of CNS axonal regeneration

The paper identifies extracellular histones as new inhibitors of CNS axonal regeneration, showing they induce growth cone collapse and can be reversed by activated protein C.

Understanding Mechanisms of Chamber-Specific Differentiation Through Combination of Lineage Tracing and Single Cell Transcriptomics

The paper uses single-cell RNA sequencing to study atrial and ventricular myocardial cell differentiation, identifying lineage trajectories and effects of retinoic acid on cardiac development.

Myeloid cell-associated resistance to PD-1/PD-L1 blockade in urothelial cancer revealed through bulk and single-cell RNA sequencing

The paper identifies proinflammatory monocytes/macrophages associated with resistance to PD-1/PD-L1 blockade in urothelial cancer using bulk and single-cell RNA sequencing.

Cell type-specific isolation and transcriptomic profiling informs glial pathology in human temporal lobe epilepsy

The paper isolates and profiles cell types in human TLE samples, revealing dysregulated pathways and an immature glial phenotype.

Multiparameter cell characterization using nanofluidic technology facilitates real-time phenotypic and genotypic elucidation of intratumor heterogeneity

The paper uses a nanofluidic platform to enable single-cell phenotypic and genetic profiling of ovarian cancer cells, revealing clonal diversity and TP53 mutation patterns associated with tumor heterogeneity.