The Fitness Cost of Therapeutic Resistance in Cancer: A Systematic Review
Bailey S. Kane, Lauren Mestas, Madds Garza, Tiara Soesilo, Meghan Hufford, Harley I. Richker, Carlo C. Maley
This paper reviews 49 experiments showing that therapy-resistant cancer clones often have a fitness cost, with two-thirds demonstrating competitive disadvantage in untreated environments.
bioRxiv · Aug 4, 2026 · PreprintCancer Biology