Diploid Hepatocytes Resist Acetaminophen-Induced Liver Injury Through Suppressed JNK Signaling
Sierra R. Wilson, Evan R. Delgado, Frances Alencastro, Rosa L. Loewenstein, Madeleine P. Leek, Leah R. Peters, Kerollos Kamel, Patrick D. Wilkinson, Siddhi Jain, Joseph D. Locker, Silvia Liu, Bharat Bhushan, Andrew W. Duncan
The paper shows diploid hepatocytes are more resistant to acetaminophen-induced liver injury due to reduced JNK signaling and mitochondrial damage.
Cell Death and Disease · Feb 3, 2026Peer-reviewedGenetics