The RNA-binding protein Imp1 promotes a Spdef transcriptional program and mucus fucosylation during necrotizing enterocolitis
Kevin A. Swift, Alexandria J. Shumway, Molly Aloia, Madeline A. Hedges, Rachel F. Pung, Moqing Liu, Cariam Rodriguez Santiago, Michael T. Shanahan, Alexander Drake, Melanie H. Hakar, Leigh Selesner, Madeline R. Kuhn, Claire Yung, Praveen Sethupathy, Sarah F. Andres
This study shows that Imp1 overexpression worsens NEC in mice by promoting a Spdef transcriptional program and increasing mucus fucosylation.
American Journal of Physiology-Gastrointestinal and Liver Physiology · Jun 5, 2026Peer-reviewedMolecular Biology