Praveen Sethupathy

This study uses single-nucleus RNA-seq to identify unique neuroepithelial features in canine acanthomatous ameloblastoma, revealing ERBB4 as a therapeutic target.

This study shows that Imp1 overexpression worsens NEC in mice by promoting a Spdef transcriptional program and increasing mucus fucosylation.

This study uses single-cell transcriptomics to analyze how vertical sleeve gastrectomy affects intestinal epithelial cell types and pathways in mice, identifying gene and pathway changes related to metabolic improvements.

This paper identifies miRNAs associated with type 2 diabetes and glycemic traits through genetic analysis of miRNA expression in human pancreatic islets.

The paper identifies distinct enhancer signatures in NASH-prone and NASH-resistant human obesity patients, revealing key genes and pathways associated with resistance.

The paper uses ChRO-seq to study chromatin dynamics during human small intestinal development, identifying enhancer activity and transcription patterns at HOX gene loci.

The paper finds that increased colonic ACE2 expression in Crohn's disease patients is associated with a higher risk of surgery within 5 years.

The paper provides multi-genomic maps of the EndoC-βH1 cell model to define gene regulatory programs in human pancreatic β cells and identifies allelic effects on cis-regulatory elements.