Borrelia burgdorferi bb0164 encodes a Na+/Ca2+ antiporter homolog with a novel role in Mn2+ homeostasis and infectivity
David Gafford-Gaby, Brandee L. Stone, Vanessa M. Ante, Savana M. Green, Kennedy L. Coleman, Madeline D. Reeves, Kristin L. Rosche, Dana K. Shaw, Jenny A. Hyde
This study identifies BB0164 as a second manganese transporter in Borrelia burgdorferi essential for infectivity and metal homeostasis, distinct from the known BmtA transporter.
bioRxiv · Jun 17, 2026 · PreprintMicrobiology