NeurosciencebioRxivPreprint
Matrix remodeling plays an etiological role in driving laminin-α2 deficient pathology
Veronica Pini, Anthony Accorsi, Ajay Kumar…·Mahasweta Girgenrath
The paper investigates fibrogenic pathways in LAMA2-related congenital muscular dystrophy, showing early ECM remodeling and myofibroblast transdifferentiation in both mouse models and human patients.