Tumor-derived Extracellular Vesicles Induce ER Stress to Drive Tolerogenic Dendritic Cell Development in the Tumor Microenvironment
X F Wang, Michael P. Plebanek, Y‐Van Nguyen, Mahere Rezazade Bazaz, Michael S. Sturdivant, Balamayooran Theivanthiran, Brent Allen Hanks
This paper shows tumor-derived extracellular vesicles induce ER stress in dendritic cells, promoting tolerogenic DCs that suppress antitumor immunity, and identifies PPAR-α inhibition as a potential therapeutic strategy.
bioRxiv · Feb 12, 2026 · PreprintImmunology