Alginate hydrogels loaded with pyruvate dehydrogenase enzyme: a novel wound dressing to disassemble Pseudomonas aeruginosa biofilm
Omid Sedighi, Nicole Roode, Tucker Johnsen, Maisie Moses, Karin Sauer, Amber L. Doiron
This paper develops PDH-loaded alginate hydrogels that reduce Pseudomonas aeruginosa biofilm biomass by 40.94% and 80.05% compared to controls, without affecting fibroblast viability.
bioRxiv · Jun 26, 2025 · PreprintBioengineering