Accurately modelling RNase H-mediated antisense oligonucleotide efficacy
Barney Hill, Maisie R. Jaques, R. Nair, Nicola Whiffin, Matthew J. A. Wood, Stephan Sanders, Peter L. Oliver, Alyssa C. Hill, Carlo Rinaldi
The paper develops ASO Atlas, a database of RNase H-mediated ASO sequences and their efficacy, and trains OligoAI, a deep learning model to predict ASO efficacy based on sequence and chemical features, reducing screening effort by 5.72-fold.
Molecular Therapy — Nucleic Acids · Jul 7, 2026Peer-reviewedBioinformatics