Adult Neuronal Expression of the Alzheimer Risk Protein CD2AP is Enriched in NGF-Responsive Basal Forebrain Neurons, where it Collocates with Rab-5 Endosomes
Lindsey Avery Fitzsimons, Mohammad Atif-Sheikh, Madison G. Mueth, Makaela Rice, Gareth R. Howell, Benjamin J. Harrison
The paper identifies CD2AP enrichment in NGF-responsive basal forebrain cholinergic neurons and links it to RAB5 endosomes, suggesting a role in retrograde trophic signaling and aging-related AD pathology.
bioRxiv · Jul 24, 2024 · PreprintNeuroscience