Gareth R. Howell

The paper shows that the MTHFR*677C>T variant in a mouse model of LOAD produces distinct transcriptional and proteomic signatures related to cerebrovascular and synaptic biology.

The paper examines how genetic and tissue-specific factors influence the neuroinflammatory response to LPS in different brain regions of mice.

Crop-OCT is an automated pipeline for analyzing OCT images to identify retinopathy in murine models, enabling the detection of regional and focal lesions across multiple diseases.

This study shows that IL1A enhances TNF-induced retinal ganglion cell death in a SARM1-dependent manner after combined insult.

This study compares two mouse models of TREM2 variants, showing both mimic Alzheimer's disease signatures in similar biological domains.

This paper characterizes cerebrovascular phenotypes in WSB.APP/PS1 mice, showing age-related CAA, transcriptomic overlap with human AD, myelin deficits, and APOE allele-dependent effects on vascular pathology.

The paper examines retinal vascular changes in Mthfr677C>T mice, finding similarities to cerebrovascular changes in AD, suggesting retinal assessment as a potential biomarker.

This study examines retinal aging across nine genetically diverse mouse strains, identifying molecular aging signatures and validating WSB and NZO as models for retinal neurodegenerative diseases.

The paper identifies CD2AP enrichment in NGF-responsive basal forebrain cholinergic neurons and links it to RAB5 endosomes, suggesting a role in retrograde trophic signaling and aging-related AD pathology.

This study shows that microglia depletion in aged mice increases optic nerve damage in glaucoma models, suggesting microglia protect against ocular hypertension-induced retinal ganglion cell loss.

This study characterizes molecular and synaptic changes in a mouse model of late-onset Alzheimer's disease under different dietary conditions, showing age-related brain volume loss and cognitive deficits.

The paper assesses neurovascular uncoupling in APOE variants, finding APOEε4/ε4 shows Type-1 uncoupling and APOEε3/ε4 shows Type-2 uncoupling in aging mice.

The paper functionally validates 11 genetic risk variants for late-onset Alzheimer's disease using a mouse model and compares transcriptomic effects to human cohorts.

The paper identifies sex-specific metabolomic differences in serum and brain of Alzheimer's disease mouse models, showing model-specific metabolic signatures that align with human APOE4 carriers.

The paper investigates age-related synaptic changes in two mouse strains, finding differential synaptic loss and efficiency in specific circuits, suggesting genetic factors influence cognitive decline resistance.

This study shows that metabolic syndrome in NZO mice reduces microglial plasticity and increases vascular interactions compared to B6J mice.

The paper shows genetic context influences microglia-synaptic interactions in AD mouse models, with differential effects in B6 and PWK strains.

This study creates a mouse model with the MTHFR 677C>T variant and shows it causes cerebrovascular deficits, supporting its use in preclinical research on vascular dementia.

This study shows that a high fat-high sugar diet interacts with the Plcg2M28L genetic variant to accelerate Alzheimer's disease-like phenotypes in mice.

This study shows that APOEϵ4 genotype interacts with exercise to influence systemic and cerebral risk factors for dementia in mice, with sex-specific effects on metabolism, brain function, and aging.

The paper identifies genetic modifiers of CEP290-mediated retinal degeneration in mice using QTL analysis and genetic crosses.

The paper identifies enriched neurodegenerative microglia signatures in EVs from Alzheimer's disease mouse models using proteomic analysis.

The paper introduces a NanoString nCounter Mouse AD panel to assess LOAD mouse models by correlating gene expression with human AD modules, showing strong correlation with RNA-Seq data.

This study identifies unique gene signatures in the cortex of young mice with APOEε3/ε4 and APOEε4/ε4 genotypes, showing distinct transcriptomic and functional differences.

This paper creates a mouse model expressing human CR1 and CR2 variants to study their role in disease.

This paper identifies a protective PLCG2 variant in Alzheimer's disease, showing enhanced PLCγ2 activation and functional changes in immune cells.

This study shows that deficiency of C1QA prevents cerebrovascular damage and white matter loss in obese mice, suggesting a role for the complement cascade in obesity-induced brain pathology.

The paper uses RNA sequencing and GLM to analyze molecular changes in B6.APP/PS1 mice brains and retinas, identifying JAK/STAT pathway activation and suggesting limited translatability of retinal changes to human AD.

The paper uses scRNA-seq to show genetic variation in microglia from different mouse strains affects their heterogeneity and response to amyloidosis in Alzheimer's disease models.

The paper uses genetic mouse models to identify transcriptomic signatures of late-onset Alzheimer’s disease by comparing mouse gene modules with human brain modules.