Exercise prevents cardiac electrical remodeling in doxorubicin-treated female mice but does not provide cardioprotection in males.
Amber V Melcher, Lauren Haflett, Lichao Tang, Katy Anne Trampel, Manas Bodapotula, Sharon Ann George
This study shows exercise prevents DOX-induced electrical remodeling in female mice but not mechanical dysfunction, while males experience mechanical issues without exercise protection.
bioRxiv · May 29, 2026 · PreprintPhysiology