A stronger transcription regulatory circuit of HIV-1C drives the rapid establishment of latency with implications for the direct involvement of Tat
Sutanuka Chakraborty, Manisha Kabi, Udaykumar Ranga
This study shows that HIV-1C's strong promoter with duplicated NF-κB motifs leads to rapid latency establishment, with Tat playing a dual role in transcriptional activation and repression.
bioRxiv · Feb 20, 2020Microbiology