A Kidney Stone Associated CLDN4 Variant Impairs Tight Junction Stability and Paracellular Ion Permeability
Forough Chelangarimiyandoab, Manu Rajinder Kumar, Kristina McNaughton, Grace Essuman, Daniel Guido Fuster, Robert Todd Alexander, Emmanuelle Cordat
The paper investigates a CLDN4 variant linked to kidney stones, showing it impairs tight junction stability and increases calcium permeability.
bioRxiv · Feb 12, 2026 · PreprintPhysiology