L-Phenylalanine restriction amplifies boron neutron capture therapy efficacy through increased L-boronophenylalanine uptake and induces activating transcription factor 4 stress response in tumor cell lines
Yuki Tamari, Rie Saba, Takushi Takata, Hiroyuki Kimura, Mao Takita, Kenta Yashiro, Minoru Suzuki, Hideya Yamazaki, Kei Yamada
This study shows that restricting L-phenylalanine increases BPA uptake in tumor cells, enhancing BNCT efficacy and inducing ATF4 stress response through LAT1/4F2HC-mediated transport.
bioRxiv · Nov 27, 2025 · PreprintCancer Biology