A systematic evaluation of data processing and problem formulation of CRISPR off-target site prediction
Ofir Yaish, Maor Asif, Yaron Orenstein
The paper evaluates CRISPR off-target site prediction methods using large-scale in vitro and in vivo datasets, highlighting the importance of data preprocessing, inactive site inclusion, and mismatch features.
Briefings in Bioinformatics · Apr 14, 2022Peer-reviewedBioinformatics