Thrombo-inflammation analyzed in a validated seven-layer platelet decision model: cellular decisions are tough problems fast and heuristically solved
Juan Pablo Prada, Johannes Balkenhol, Özge Osmanoğlu, Maral Afshar, Martin Kaltdorf, Sarah Hofmann, Sebastian von Mammen, Katrin Gertrud Heinze, Harald Schulze, Thomas Dandekar
The paper shows platelet signaling cascades are complex decision problems solved efficiently using heuristics, leading to fast responses but potential chronic inflammation under stress.
bioRxiv · Aug 2, 2024 · PreprintBioinformatics