Analysis of somatic mutations in senescent cells using single-cell whole-genome sequencing
Lei Zhang, Marco De Cecco, Moonsook Lee, Xiaoxiao Hao, Alexander Y. Maslov, Cristina Montagna, Judith Campisi, Xiao Dong, John M. Sedivy, Jan Vijg
This study uses single-cell whole-genome sequencing to compare mutation burdens in early passage and deeply senescent human fibroblasts, finding increased single-nucleotide variations and aneuploidies in senescent cells.
Aging Biology · Jun 29, 2023Peer-reviewedGenomics