Lei Zhang

SORT disentangles multilevel gene programs across heterogeneous spatial transcriptomic atlases

SORT identifies multilevel gene programs and their spatial activities across diverse spatial transcriptomic datasets, revealing both shared and sample-specific patterns.

Unraveling APA dynamics during quiescence transitions reveals Pabp modulation of sod2 expression via APA to regulate cellular quiescence

This study maps APA dynamics during quiescence transitions in fission yeast and identifies Pabp's role in regulating sod2 expression via APA to control cellular quiescence.

Cyclic-thiourea ionizable lipids program multilamellar mRNA-LNPs for sustained expression, frozen-storage stability and potent vaccine immunotherapy

This paper introduces a cyclic-thiourea ionizable lipid (HI-62) that forms multilamellar mRNA-LNPs with sustained expression, stability, and potent vaccine immunotherapy effects.

VGLL4 promotes thoracic aortic aneurysm and dissection by disrupting extracellular matrix homeostasis via WISP1-mediated TIMP3/MMP9 imbalance

This study identifies VGLL4 as a mechanosensitive regulator of TAAD by disrupting ECM homeostasis through the WISP1-TIMP3/MMP9 axis.

Spatial Glyco-Codes Define Human Liver Pathology and Progression

This study introduces spatial-GPT, a platform for spatial glycan, protein, and transcriptome profiling in human liver tissues, revealing glyco-codes that define disease states and progression.

Locus-specific Convergent Evolution and Interchromosomal Rearrangements Contribute Type I Interferon Diversification in Amniotes

The paper identifies conserved IFN-I loci and lineage-specific expansions in amniotes, revealing convergent evolution and interchromosomal duplications contributing to IFN-I diversity.

A transcriptomic analysis reveals shared and inducer-specific expression patterns of cellular senescence

The paper analyzes transcriptomic changes in human fibroblasts under different senescence-inducing conditions, finding shared pathway-level responses and inducer-specific gene-level variations.

Age-associated increases in inter-individual gene expression variability across human tissues

The paper identifies age-related increases in inter-individual gene expression variability using the Gene Stability Score in GTEx data, showing distinct biological impacts and non-random network architecture.

FASN Inactivation-induced Progranulin (GRN) Expression Promotes Lysosome-dependent Cell Death to Suppress Leukemogenesis

This study shows that inhibiting FASN leads to lysosome-dependent cell death via GRN expression, suppressing leukemogenesis in myeloid leukemia.

Mast cell-driven adipocyte lipolysis promotes post-expansive VAT atrophy and ectopic hepatic steatosis

This study identifies mast cells and their derived serotonin as drivers of adipocyte lipolysis, leading to visceral fat atrophy and hepatic steatosis in obesity.

Therapeutic Potential of a Tectorigenin Derivative (TED) in Herpetic Stromal Keratitis: Antiviral and lmmunomodulatory Mechanisms

This study evaluates TED's anti-HSV-1 effects and therapeutic efficacy in HSK, finding it reduces viral loads and modulates immune responses through TLR pathway inhibition and immune cell regulation.

Novel Function of Arylalkalamine N-acetyltransfe- rase-1 in Modulating Host Coagulation and Blood Feeding in Aedes aegypti

This study identifies aaNAT1's role in modulating host coagulation and blood feeding in Aedes aegypti by binding norepinephrine and affecting platelet aggregation.

General purpose genotypes and evolution of higher plasticity in clonality underlie knotweed invasion

The paper examines phenotypic variation in Reynoutria japonica across native and introduced ranges, finding higher clonality and plasticity in introduced populations compared to native Chinese populations.

Evidence for negative selection against somatic mutations in fibroblasts with high N-ethyl-N-nitrosourea-induced mutation load

The paper shows that human fibroblasts undergo negative selection against harmful mutations, maintaining growth despite high mutation loads.

Analysis of somatic mutations in senescent cells using single-cell whole-genome sequencing

This study uses single-cell whole-genome sequencing to compare mutation burdens in early passage and deeply senescent human fibroblasts, finding increased single-nucleotide variations and aneuploidies in senescent cells.

AutoGenome: An AutoML Tool for Genomic Research

AutoGenome is an automated deep learning framework for genomic profiling data that uses a residual fully-connected neural network and AutoML to train high-performance models.

AutoGenome V2: New Multimodal Approach Developed for Multi-Omics Research

AutoGenome V2 integrates multi-omics data using a novel multimodal deep learning approach, achieving state-of-the-art results in four tasks.