Natural variants of von Willebrand factor R1205 causing von Willebrand disease with accelerated von Willebrand factor clearance: in silico docking models and energetics of the interaction with both LRP1 and GpIb A1 domain
Monica Sacco, Stefano Lancellotti, Antonietta Ferretti, Maria Basso, Leonardo Di Gennaro, Giancarlo Castaman, Raimondo DE CRISTOFARO
The paper uses computational models to show how R1205 variants in von Willebrand factor alter interactions with LRP1 and GPIb, explaining disease mechanisms and offering therapeutic insights.
PLoS Computational Biology · Dec 3, 2025Peer-reviewedBiochemistry