A mathematical model of flow-mediated coagulation identifies factor V as a modifier of thrombin generation in hemophilia A
Kathryn G. Link, Michael T. Stobb, Matthew G. Sorrells, Maria Bortot, Katherine A. Ruegg, Marilyn J. Manco‐Johnson, Jorge A. Di Paola, Suzanne Sindi, Aaron L. Fogelson, Karin Leiderman, Keith B. Neeves
The paper uses a mathematical model of coagulation under flow to identify factor V as a modifier of thrombin generation in hemophilia A, showing its interaction with factor VIII.
Journal of Thrombosis and Haemostasis · Sep 28, 2019Peer-reviewedSystems Biology