Keith B. Neeves

This paper develops a 3D-bioprinted model of pulmonary artery adventitia using female patient-derived cells to show that estrogen signaling mediates fibroblast activation in PAH, with implications for drug testing.

This paper develops micrometer-scale tPA beads that enhance plasmin generation and fibrinolysis, achieving rapid thrombus removal in a mouse stroke model with lower doses than standard tPA.

This study uses isotopically nonstationary 13C metabolic flux analysis to measure carbon fluxes in resting and thrombin-activated human platelets, revealing metabolic shifts during activation.

The paper uses a mathematical model of coagulation under flow to identify factor V as a modifier of thrombin generation in hemophilia A, showing its interaction with factor VIII.