A miR-124-mediated post-transcriptional mechanism controlling the cell fate switch of astrocytes to induced-neurons
Elsa Papadimitriou, Paraskevi N. Koutsoudaki, Irini Thanou, Dimitra Karagkouni, Timokratis Karamitros, Dafni Chroni-Tzartou, Maria Gaitanou, Christos Gkemisis, Maria Margariti, Evangelia Xingi, Socrates J. Tzartos, Artemis G. Hatzigeorgiou, Dimitra Thomaidou
This study shows miR-124 can drive astrocyte-to-neuron reprogramming independently, by targeting Zfp36l1 and enhancing neurogenic pathways, with ISX9 improving efficiency and maturation.
Stem Cell Reports · Mar 23, 2023Peer-reviewedNeuroscience