Nanocarrier-driven dual targeting VCAM-1/Collagen IV enables RNA interference-mediated silencing of Smad3 and Runx2 to mitigate aortic valve disease
Geanina Voicu, Cristina Ana Mocanu, Florentina Safciuc, Maria Anghelache, Mihaela Turtoi, Mariana Deleanu, Maya Simionescu, Ileana Mânduțeanu, Manuela Călin
This study develops dual-targeted nanocarriers to deliver shRNA against Smad3 and Runx2, reducing aortic valve calcification in a mouse model.
bioRxiv · Jul 31, 2025 · PreprintPathology