AI-enhanced cardiac digital twins extend drug proarrhythmic risk assessment through experimental data uncertainty propagation and overdose exploration: a loperamide case study
Paula Dominguez-Gomez, Alberto Zingaro, Caterina Balzotti, Michael Leitner, Noelia Jacobo‐Piqueras, Mariano Vazquez, Georg F. Rast, Jazmín Aguado‐Sierra
The paper uses AI-enhanced cardiac digital twins to assess drug proarrhythmic risk by propagating experimental uncertainty and simulating extreme exposures, finding sex-specific arrhythmogenic thresholds for loperamide.
Regulatory Toxicology and Pharmacology · Jun 1, 2026Peer-reviewedBioengineering