Widespread cryptic RAG-mediated recombination in developing T lymphocytes
Daniel Sobral, Joana Silva, Diogo Santos, José Bártholo Pereira Leal, Salvatore Spicuglia, Jocelyne Demengeot, Marie Bonnet
The paper identifies widespread cryptic RAG-mediated recombination events in mouse thymocytes beyond known antigen receptor loci, showing these events are not explained by local genetic or epigenetic features.
bioRxiv · Sep 4, 2026 · PreprintImmunology