Mechanosensitive Stanniocalcin-1 Attenuates Pulmonary Arterial Hypertension by Suppressing Smooth Muscle Cell Proliferation
Mariko Kogami, Yuko Kato, Satoko Ito, Keiko Uchida, Hana Inoue, Shota Tanifuji, Mayumi Yokotsuka, Yoshinari Yamamoto, Toshitaka Nagao, Shinji Abe, Roger R. Reddel, Kazufumi Nakamura, Utako Yokoyama
This study identifies STC1 as a pressure-induced gene in IPAH PASMCs that suppresses proliferation and vascular remodeling through PIEZO1, suggesting STC1 as a therapeutic target.
bioRxiv · Oct 13, 2025 · PreprintMolecular Biology