Thermodynamic Model and Experiments Indicate Kinetically Trapped States in Ionisable Lipid Nanoparticles
Ekaterina Kostyurina, Akhil Sudarsan, Marina Huber, Christoph Westerhausen, Nadine Schwierz, Joachim Raedler, Susanne Liese
This study combines experiments and simulations to develop a continuum model explaining pH-dependent mesophase transitions in ionizable lipid nanoparticles and identifies metastable states.
bioRxiv · Oct 30, 2026 · PreprintBiophysics