Nadine Schwierz

This study combines experiments and simulations to develop a continuum model explaining pH-dependent mesophase transitions in ionizable lipid nanoparticles and identifies metastable states.

The paper assesses the transferability of ion force fields to OPC water and introduces a new force field, MS/G-LB(OPC), that improves accuracy for single-ion and ion-pairing properties.

This paper uses coarse-grained simulations and reflectivity data to study RNA-lipid interactions at interfaces, showing how RNA structure affects binding and validating simulation results with experimental data.

This study measures DNA twist at high salt concentrations using magnetic tweezers and simulations, showing ion-specific changes but no evidence for a C-form transition.

This study shows that ubiquitin activates SPRTN protease to degrade DNA-protein crosslinks, maintaining genome stability and preventing disease.

This study reveals the structural basis of OAS2 regulation and its antiviral function, showing how it discriminates RNA length and restricts viruses like coronaviruses.

This study investigates how buffer type affects lipid nanoparticle structure and transfection efficiency, finding citrate buffer enhances mRNA expression through altered phase transitions.

The paper uses AI to resolve magnesium binding pathways to RNA, revealing solvent structures and solute-solvent coupling mechanisms.