BRCA2 and RAD54B FxPP motifs Bind DMC1 Filaments through Persistent and Transient Interfaces
Dupaigne Pauline, Simona M. Miron, Sonia Baconnais, Pierre Legrand, Sari E. van Rossum-Fikkert, Koichi Sato, Atifa Majeed, Marine Le Hingrat, Malika Ouldali, Alex N. Zelensky, Roland Kanaar, Philippe Cuniasse, Sophie Zinn‐Justin
This study identifies and characterizes P-motifs in BRCA2 and RAD54B that bind to DMC1 filaments through stable and transient interactions, revealing structural insights into their roles in meiotic recombination.
bioRxiv · Jul 27, 2026 · PreprintBiochemistry