Interaction between variants in CLU and MS4A4E modulates Alzheimer’s disease risk
Mark T. W. Ebbert, Kevin L. Boehme, Mark E. Wadsworth, Lyndsay A. Staley, for the Alzheimer's Disease Neuroimaging Initiativ, Alzheimer's Disease Genetics Consortium, Shubhabrata Mukherjee, Paul K. Crane, Perry G. Ridge, John S. K. Kauwe
The paper evaluates gene-gene interactions between CLU and MS4A4E variants in Alzheimer’s disease using a large dataset, finding a significant interaction and estimating its population attributable fraction.
bioRxiv · Oct 13, 2015Genetics