A General Approach to Adjusting Genetic Studies for Assortative Mating
Marta Bilghese, Regina Manansala, Dhruva Jaishankar, Jonathan Jala, Daniel Jacob Benjamin, Miles Kimball, Paul Livermore Auer, Michael A. Livermore, Patrick Turley
This paper introduces a method to adjust genetic studies for assortative mating using polygenic indexes, finding that assortative mating inflates genetic correlation estimates between health traits and education by 14% on average.
bioRxiv · Sep 1, 2023 · PreprintGenomics