Regina Manansala

Whole Genome Sequencing Based Analysis of Inflammation Biomarkers in the Trans-Omics for Precision Medicine (TOPMed) Consortium

The paper analyzes inflammation biomarkers using whole-genome sequencing from the TOPMed consortium, identifying both single-variant and rare variant associations with inflammatory traits.

A General Approach to Adjusting Genetic Studies for Assortative Mating

This paper introduces a method to adjust genetic studies for assortative mating using polygenic indexes, finding that assortative mating inflates genetic correlation estimates between health traits and education by 14% on average.

Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

This study identifies 5,552 blood-cell trait-variant associations across 746,667 individuals from 5 global populations, including 71 novel loci and ancestry-specific variants not found in European ancestry populations.

The Polygenic and Monogenic Basis of Blood Traits and Diseases

This study identifies 5,106 new genetic variants associated with blood cell traits using large-scale GWAS, highlighting the polygenic and monogenic basis of hematopoiesis.

Individualized multi-omic pathway deviation scores using multiple factor analysis

This paper introduces padma, a pathway-centric tool that quantifies individualized multi-omic deviations in cancer, correlating them with clinical outcomes in breast and lung cancer.