Matrix biophysical cues drive transient or prolonged breast cancer dormancy programmes
Unai Heras, José Miguel Pardo-Sánchez, Jone Berasain, Iune Toledo, Leire Iturriaga, Itxaso Calafel, Robert Aguirresarobe, Guillermo de Cárcer, Julio A. Aguirre‐Ghiso, E. Arizaga Batiz, Marta Fernandez, Rosa M Zubizarreta Susperregui, Ana Legórburu, Ana Cristina Riestra, Oihane Mitxelena‐Iribarren, Amaia Cipitria
This study shows that matrix stiffness influences breast cancer cell dormancy states, with soft matrices inducing transient dormancy and stiff matrices causing prolonged dormancy.
bioRxiv · Oct 29, 2026 · PreprintBioengineering