Conserved Aberrant Developmental Trajectories of Human and Mouse SBMA Motor Neurons
Helen E. Devine, Martha J Roberts, Oliver Jonathan Ziff, Michael G. Hanna, Linda Greensmith, Rickie Patani, Bilal Ahmad Malik
This study identifies conserved transcriptional changes in motor neurons from human and mouse SBMA models, revealing shared dysregulation in pathways like spliceosome, cell cycle, and mitochondrial function across developmental and disease stages.
bioRxiv · Sep 17, 2025 · PreprintNeuroscience