Author

Oliver Jonathan Ziff

The Francis Crick InstituteORCID 0000-0002-1504-7245Unclaimed ORCID profile · follow to get notified of new preprints

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Rickie PataniiD· 3 shared Argyro AlatzaiD· 1 shared Benjamin GaletiD· 1 shared Bilal Ahmad MalikiD· 1 shared Charles ArberiD· 1 shared Dervis A. M. SalihiD· 1 shared Doaa M. TahaiD· 1 shared Fiona DucotterdiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

Rickie PataniORCID

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3 papers

Recent·Most cited

Conserved Aberrant Developmental Trajectories of Human and Mouse SBMA Motor Neurons

Helen E. Devine, Martha J Roberts, Oliver Jonathan Ziff, Michael G. Hanna, Linda Greensmith, Rickie Patani, Bilal Ahmad Malik

This study identifies conserved transcriptional changes in motor neurons from human and mouse SBMA models, revealing shared dysregulation in pathways like spliceosome, cell cycle, and mitochondrial function across developmental and disease stages.

bioRxiv · Sep 17, 2025 · PreprintNeuroscience

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis

Oliver Jonathan Ziff, Gustavo Morrone Parfitt, Sarah Jolly, Jackie M. Casey, Lucy Granat, Satinder K. Samra, Núria Setó‐Salvia, Argyro Alatza, Leela Phadke, Benjamin Galet, Philippe Ravassard, Marie‐Claude Potier, John Hardy, Dervis A. M. Salih, Paul John Whiting, , Charles Arber

This study shows that PSEN1 mutations disrupt regulated intramembrane proteolysis in astrocytes, leading to enhanced inflammatory responses and contributing to familial Alzheimer's disease progression.

Molecular Neurodegeneration · Jun 20, 2025Peer-reviewedNeuroscience

An aberrant cytoplasmic intron retention programme is a blueprint for ALS-related RBP mislocalization

Giulia E. Tyzack, Jacob Neeves, Pierre Klein, Hamish Crerar, Oliver Jonathan Ziff, Doaa M. Taha, Raphaëlle Luisier, Nicholas M. Luscombe, Rickie Patani

The paper identifies aberrant cytoplasmic intron-retaining transcripts (IRTs) in ALS and shows their association with RBP mislocalization.

bioRxiv · Jul 20, 2020 · PreprintNeuroscience