A tripartite structure, the complex nuclear receptor element (cNRE), is a cis-regulatory module of viral origin required for atrial chamber preferential gene expression
Luana Nunes Santos, Ângela Maria Sousa Costa, Martin Nikolov, Allysson Coelho Sampaio, Frank E. Stockdale, Gang F Wangø, Hozana Andrade Castillo, Mariana B. Grizante, Stefanie Dudczig, Michelle Vasconcelos, Nadia A Rosenthal, Patricia Regina Jusuf, Paulo Sérgio Lopes de Oliveira, Tatiana Guimarães de Freitas Matos, William Nikovits, , José Xavier‐Neto
The paper identifies a viral-derived cis-regulatory element, cNRE, that drives atrial-specific gene expression by combining activation and repression motifs.
bioRxiv · Nov 18, 2021 · PreprintDevelopmental Biology