Nadia A Rosenthal

This study shows that FAP-targeted BiTE(R) molecules, intended to reduce cardiac fibrosis, instead worsen heart function by triggering harmful immune responses.

This study shows that aging disrupts circadian rhythms, leading to sex- and time-of-day-dependent changes in senescence and inflammatory pathways in mice.

The paper shows CD4+ T cells inhibit digit-tip regeneration by attacking progenitor cells, which can be counteracted by T regulatory cells or RANKL.

The paper identifies a composite transcriptome signature with high distal heritability that explains 30% of metabolic trait variation across species.

The paper models metabolic disease susceptibility and resilience in genetically diverse mice by analyzing diet-induced metabolic responses across three strains.

The paper characterizes the CAST/EiJ mouse strain as a model for severe COVID-19 by showing it develops high viral burdens, severe lung pathology, and cytokine dysregulation leading to mortality.

The paper introduces 11 wild-derived inbred mouse strains with expanded genomic and phenotypic diversity, enhancing the scope of biomedical research.

The paper identifies three genetic loci influencing mitochondrial proteins and heart hypertrophy in mice using proteomics and association mapping.

The paper identifies a viral-derived cis-regulatory element, cNRE, that drives atrial-specific gene expression by combining activation and repression motifs.

This paper develops a 3D spatial transcriptomic atlas of the mouse heart and provides a web tool for analysis and visualization.

This study shows that metformin prevents cardiac dysfunction in a mouse model of adult congenital heart disease under metabolic stress.