A Bitopic mTORC Inhibitor Reverses Neural Phenotypes in a Tuberous Sclerosis Complex Murine Model of SEGA-like Hamartomas
Sulagna Mukherjee, Matthew J Wolan, Mary K. Scott, Victoria A. Riley, Aidan M. Sokolov, David M. Feliciano
This study shows that Rapalink-1, a bitopic mTORC1 inhibitor, reverses neural phenotypes in a TSC SEGA mouse model by reducing hamartoma size and dendrite arbors.
Scientific Reports · Jul 1, 2025Peer-reviewedNeuroscience