Hoxb5+ fetal liver hematopoietic stem cells establish lifelong hematopoiesis and exhibit enhanced ITGA4-dependent engraftment
Allison M. Banuelos, Michelle Baez, Leyla Yılmaz, Elle Koren, Allison Zhang, Monika Żukowska, Nicole L. Womack-Gambrel, Mary Moffitt, Andrew T. Burden, Victoria L. Mascetti, Ruby Honjol, Jinyi Xiang, Rahul Sinha, Irving L. Weissman
This study identifies Hoxb5+ fetal liver HSCs as capable of lifelong hematopoiesis and shows their enhanced ITGA4-dependent engraftment compared to adult HSCs.
bioRxiv · Jul 1, 2026 · PreprintDevelopmental Biology