Irving L. Weissman

An InDel Genomic Variant within a Bifunctional Super-Enhancer for LINC00636 and CD47 Regulation in Breast Cancer

The paper identifies an insertion-deletion variant in a super-enhancer regulating LINC00636 and CD47 in breast cancer, showing its impact on chromatin accessibility and tumor-promoting features.

Regional Signaling Controls Stem Cell-Mediated Regeneration in an Invertebrate Chordate

The paper identifies region-specific signaling cues that control stem cell-mediated regeneration in the invertebrate chordate Ciona robusta.

Anatomical and functional organisation of the cholinergic nervous system in the tunicate Botryllus schlosseri

This study maps the anatomical and functional organization of the cholinergic system in Botryllus schlosseri, revealing a dual-effector system coordinating muscular and ciliary networks.

Lifelong Invertebrate Chordate Central Nervous System Regeneration is Driven by a Migrating Pool of Conserved Neural Stem Cells Program

This study identifies a conserved neural stem cell pool driving continuous CNS regeneration in Botryllus schlosseri, showing aging disrupts this process.

Neogenin-1 marks myeloid-primed fetal hematopoietic stem cells that undergo progressive lineage-restriction with age

The paper identifies Neogenin-1 as a marker for myeloid-biased fetal HSCs and shows that lineage bias is established early and reinforced with age.

Hoxb5 Enriches Long-Term Hematopoietic Stem Cell Activity within the Mouse Fetal Liver Phenotypic HSC Compartment

This study identifies Hoxb5 as a marker for long-term hematopoietic stem cells in fetal liver, showing its utility in purification and revealing developmental regulation.

Hoxb5+ fetal liver hematopoietic stem cells establish lifelong hematopoiesis and exhibit enhanced ITGA4-dependent engraftment

This study identifies Hoxb5+ fetal liver HSCs as capable of lifelong hematopoiesis and shows their enhanced ITGA4-dependent engraftment compared to adult HSCs.

Human Haematopoietic Stem Cells released into circulation following mobilization express multiple G0-associated quiescence markers

The paper investigates mobilized human HSC and finds they rapidly express G0-associated quiescence markers despite recent cell divisions.

Isolation of postnatal human neural stem cells

The paper isolates and characterizes two postnatal human neural stem cell subsets, showing their fate biases and decline in frequency over time.

Xenophagocytosis blockade enhances interspecies chimerism

This study identifies xenophagocytosis as an innate immune barrier that limits interspecies chimerism and shows that blocking it enhances donor cell engraftment in mouse embryos.

Somatic mutations reveal the ontogeny of human microglia

This study uses somatic mutations to track marrow-derived cell infiltration into the human brain, finding widespread microglia replenishment and a protective link between clonal hematopoiesis and Alzheimer's disease.

Survival Benefits Outweigh Germline Competition Costs in Kin Chimeras

The study quantifies survival benefits and germline competition costs of chimerism in Botryllus schlosseri, finding survival advantages outweigh competition costs.

mRNAbow: A versatile gene expression system for multiplexed fluorescent imaging using optimized in vitro transcribed mRNA

The paper develops mRNAbow, a system for generating low-toxicity mRNAs for multiplexed fluorescent imaging in diverse cellular and organismal systems.

Germline stem cell isolation, lineage tracing, and aging in a protochordate

This study investigates age-related changes in germline stem cells (GSCs) in the protochordate Botryllus schlosseri using single-cell RNA sequencing and transplantation assays, revealing that GSCs, not gametes, drive reproductive aging.

Beyond polyA: scalable single-cell total RNA-seq unifies coding and non-coding transcriptomics

This paper introduces a method to capture non-coding RNAs in single-cell RNA-seq, revealing new insights into gene regulation in immune cells, infected hepatocytes, and brain development.

Modeling Glioma Intratumoral Heterogeneity with Primary Human Neural Stem and Progenitor Cells

This study models glioma intratumoral heterogeneity using primary human neural stem and progenitor cells, showing how cell-of-origin influences tumor subtypes.

Electrical Stimulation Rejuvenates Tunicates: Altered Stem Cell and Immune Activity

The paper shows that pulsatile electrical current improves survival, regeneration, and reproduction in Botryllus schlosseri by altering stem cell and immune activity through transcriptomic changes.

High-Throughput Screening on Primary Tumor-Associated Microglia and Macrophages Identifies HDAC Inhibitors as Enhancers of Phagocytosis and Potent Partners for Immunotherapy in Glioblastoma

This study identifies HDAC inhibitors as enhancers of TAM phagocytosis and synergistic partners for immunotherapy in GBM through high-throughput screening.

Metabolically purified human stem cell-derived hepatocytes reveal distinct effects of Ebola and Lassa viruses

This study uses metabolically purified human hepatocytes to show that Ebola and Lassa viruses have distinct effects on liver cells.

TMX1, a disulfide oxidoreductase, is necessary for T cell function through regulation of CD3zeta

This study identifies TMX1 as a critical regulator of T cell function by modulating CD3zeta stability and TCR signaling.

P66 is a bacterial mimic of CD47 that binds the anti-phagocytic receptor SIRPα and facilitates macrophage evasion by Borrelia burgdorferi

This study identifies P66, a bacterial protein mimicking CD47, which binds SIRPα to evade macrophage phagocytosis, and shows its role in Lyme Disease pathogenesis.

Cell type-specific aging clocks to quantify aging and rejuvenation in regenerative regions of the brain

This study develops cell type-specific aging clocks using single-cell transcriptomic data to quantify aging and rejuvenation in the brain's neurogenic regions.

Secretoglobin family 1D member 2 (SCGB1D2) protein inhibits growth of Borrelia burgdorferi and affects susceptibility to Lyme disease

The paper identifies a genetic variant in SCGB1D2 that increases Lyme disease susceptibility and shows that the wild-type protein inhibits Borrelia burgdorferi growth more effectively than the variant.

Activated interstitial macrophages are a predominant target of viral takeover and focus of inflammation in COVID-19 initiation in human lung

This paper identifies activated interstitial macrophages as a key target of SARS-CoV-2 infection in human lung tissue, showing their role in viral takeover, inflammation, and fibrosis.

Tabula Microcebus: A transcriptomic cell atlas of mouse lemur, an emerging primate model organism

The paper creates a comprehensive cell atlas of mouse lemurs using single-cell RNA sequencing, identifying over 750 cell types and comparing their molecular profiles to humans, mice, and macaques.

Coronary blood vessels from distinct origins converge to equivalent states during mouse and human development

The paper shows that coronary endothelial cells in mouse and human hearts initially show lineage-specific transcriptional differences but later become influenced by location, with adult cells becoming more homogeneous.

Revealing conserved mechanisms of neurodegeneration in a colonial chordate

The paper studies neurodegeneration in the colonial chordate Botryllus schlosseri, finding conserved mechanisms between tunicates and humans.

Overexpression of CD47 is associated with brain overgrowth in 16p11.2 deletion syndrome

The paper investigates the role of CD47 overexpression in 16p11.2 deletion syndrome, showing it contributes to brain overgrowth by inhibiting phagocytosis in neural progenitor and oligodendrocyte progenitor cells.

Global Age-Specific Patterns of Cyclic Gene Expression Revealed by Tunicate Transcriptome Atlas

The paper identifies age-specific circadian gene expression patterns in Botryllus schlosseri and links them to aging phenotypes and pathways.

A molecular cell atlas of the human lung from single cell RNA sequencing

The paper creates a comprehensive molecular cell atlas of the human lung using single-cell RNA sequencing, identifying 58 cell populations including 14 new types and revealing evolutionary changes in lung cell types.